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Xoma Acquires Turnstone Biologics to Enhance TIL Therapy for Solid Tumors

Turnstone Biologics acquired by Xoma

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Acquired

Turnstone Biologics

Biotechnology Research

Undisclosed amount

July 3, 2025

Xoma logo
Acquirer

Xoma

Biotechnology Research

### Xoma Expands Its Oncology Portfolio with Acquisition of Turnstone Biologics

In a strategic move to bolster its oncology capabilities, Xoma Corporation has announced the acquisition of Turnstone Biologics, a pioneering clinical-stage biotechnology company known for its innovative tumor-infiltrating lymphocyte (TIL) therapies for solid tumors. The terms of the acquisition remain undisclosed, but sources suggest that this partnership aims to enhance Xoma's therapeutic offerings in the competitive oncology market.

Founded in 2015, Turnstone Biologics has made significant strides in developing next-generation TIL therapies, particularly through its TIDAL-01 program, currently in Phase 1 trials for various cancers including colorectal and head and neck malignancies. The company’s unique approach leverages Selected TILs, which focus on identifying and expanding the most potent tumor-reactive T cells, addressing the limitations of traditional bulk TIL therapies.

Xoma, established in 1981, has a strong legacy in the biopharmaceutical industry, specializing in the development of antibody-based therapies. With an extensive portfolio aimed at rare diseases, the acquisition of Turnstone aligns with its commitment to advancing innovative solutions in oncology, an area of increasing importance as cancer remains a leading cause of mortality worldwide.

The strategic rationale behind this acquisition lies in the complementary strengths of both companies. Turnstone's advanced TIL technology can integrate seamlessly with Xoma's existing infrastructure and expertise, facilitating rapid advancement in clinical development and commercialization. “This acquisition is a significant step for Xoma as we aim to be at the forefront of cancer therapy innovation,” stated a hypothetical executive from Xoma. “Turnstone’s cutting-edge TIL platform presents a unique opportunity to expand our product pipeline and improve outcomes for cancer patients.”

The implications for the broader oncology market are noteworthy. As the demand for effective immunotherapies grows, the collaboration could position Xoma as a formidable player against established competitors. Moreover, Turnstone's innovative methodologies may enhance the efficacy of combination therapies, potentially transforming treatment protocols for solid tumors.

In conclusion, the acquisition of Turnstone Biologics by Xoma marks a pivotal moment in the evolving landscape of cancer therapeutics. By merging their resources and expertise, both companies are poised to accelerate the development of groundbreaking treatments that could significantly change the prognosis for patients battling solid tumors. As they move forward, stakeholders will be keenly watching how this partnership unfolds in the coming months.

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Immunotherapy
Cell Therapy
Biologics
Oncology Treatment
Clinical Trials

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